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Artigos Científicos

segunda-feira, 10 dezembro 2018 14:54

Methylphenidate Alters Functional Connectivity of Default Mode Network in Drug-Naive Male Adults With ADHD

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Felipe Almeida Picon1, 2, 3, João Ricardo Sato3, 4, Maurício Anés1, 2Leonardo Modesti Vedolin5, Alessandro André Mazzola6, Bruna Bressan Valentini7, Renata Basso Cupertino1, 8, Rafael Gomes Karam1, Marcelo Moraes Victor1, 2Vitor Breda1, 2, Katiane Silva1, 2, Neivo da Silva, Jr9, Claiton Henrique Dotto Bau1, 2, 8, Eugenio Horacio Grevet1, 2, Luis Augusto Paim Rohde1, 2, 3

1
ADHD Outpatient Program – Adult Division, Hospital de Clínicas de Porto Alegre, Brazil
2
Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
3
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil
4
Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo André, Brazil
6
Grupo DASA, São Paulo, Brazil
6
PhyMED Medical Physics and Radioprotection Consulting, Porto Alegre, Brazil
7
Hospital Moinhos de Vento, Porto Alegre, Brazil
8
Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
9
Nuclear Medicine Laboratory, Santa Casa de Misericórdia, Porto Alegre, Brazil

Journal of Attention Disorders: SAGE Journals

December 10, 2018


ABSTRACT:

Objective: This study evaluated the hypothesis that methylphenidate immediate release (MPH-IR) treatment would improve Default Mode Network (DMN) within-connectivity.

Method: Resting-state functional connectivity of the main nodes of DMN was evaluated in a highly homogeneous sample of 18 drug-naive male adult participants with ADHD.

Results: Comparing resting-state functional connectivity functional magnetic resonance imaging (R-fMRI) scans before and after MPH treatment focusing exclusively on within-DMN connectivity, we evidenced the strengthening of functional connectivity between two nodes of the DMN: posterior cingulate cortex (PCC) and left lateral parietal cortex (LLP).

Conclusion: Our results contribute to the further understanding on how MPH affects functional connectivity within DMN of male adults with ADHD and corroborate the hypothesis of ADHD being a delayed neurodevelopmental disorder.


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