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Artigos Científicos

quinta-feira, 01 agosto 2019 18:05

Association of Psychiatric Comorbidity With the Risk of Premature Death Among Children and Adults With Attention-Deficit/Hyperactivity Disorder

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Shihua Sun, MD1, Kuja-Halkola, Ralf1, Faraone, Stephen V.2,3, D’Onofrio, Brian M.1,4, Dalsgaard, Søren5,6,7, Chang, Zheng1, Larsson, Henrik1,8.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Department of Psychiatry, State University of New York (SUNY) Upstate Medical University, Syracuse
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse
Department of Psychological and Brain Sciences, Indiana University, Bloomington
National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
iPSYCH–The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark
Department for Child and Adolescent Psychiatry, Hospital of Telemark, Kragerø, Norway
School of Medical Sciences, Örebro University, Örebro, Sweden

JAMA Psychiatry 

Published online August 7, 2019

Key Points

Question: Is attention-deficit/hyperactivity disorder (ADHD) associated with premature death, and what is the role of psychiatric comorbidity?

Findings: This cohort study of Swedish register data of 86 670 individuals with ADHD found that ADHD was associated with elevated risk of premature death, and psychiatric comorbidity played an important role for the all-cause and cause-specific associations in adults. Early-onset psychiatric comorbidity was mainly associated with the risk of natural deaths whereas later-onset psychiatric comorbidity was mainly associated with death due to unnatural causes, including suicide and unintentional injury.

Meaning: These findings suggest that health care professionals should closely monitor specific psychiatric comorbidities in individuals with ADHD to identify high-risk groups and implement prevention efforts.

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